eNOS and H
2
O
2
– Modulated Signal Transduction

Slide1

 

 

For many years, reactive oxygen species (ROS) were viewed as pathological molecules, implicated in disease states ranging from atherosclerosis to neurodegeneration. More recently, the stable ROS hydrogen peroxide (H2O2) has been identified as a physiological signaling molecule.  We have used the H2O2 biosensor HyPer2 to explore the intracellular signaling pathways connecting receptor activation with H2O2–dependent signaling to eNOS in endothelial cells and cardiac myocytes.

 

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