Saravi S, Eroglu E, Waldeck-Weiermair M, Sorrentino A, Steinhorn B, Belousov V, Michel T. Differential endothelial signaling responses elicited by chemogenetic hydrogen peroxide synthesis. Redox Biology 2020, 36:101605, https://doi.org/10.1016/j.redox.2020.101605
Montiel V…Michel T… Balligand JL. Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. Sci Transl Med. 2020;12(564):eaay2176. doi: 10.1126/scitranslmed.aay2176. PMID: 33028705.
Pak VV…Michel T, Vriz S, Messens J, Belousov VV. Ultrasensitive genetically encoded indicator for intracellular hydrogen peroxide identifies novel roles for cellular oxidants in cell migration and mitochondrial function. Cell Metabolism 2020, 31:642-653.
Eroglu E, Saravi S, Sorrentino A, Steinhorn B, Michel T. Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods. Proc Natl Acad Sci USA 2019, 116:20210-20217. PMID: 31527268.
Natalie M, Michel T, Belousov V. Which antioxidant systems shape intracellular oxidant gradients? Antioxidants Redox Signal 2019. doi: 10.1089/ars2018.7697. PMCID:PMC6657290.
Andrea Sorrentino, Benjamin Steinhorn, Luca Troncone, Seyed Soheil Saravi, Sachin L Badole, Emrah Eroglu, Marie Foley Kijewski, Sanjay Divakaran, Marcelo Di Carli, Thomas Michel
Steinhorn B, Sorrentino B, Badole S, Bogdanova Y, Belousov V, Michel T. Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction. December 2018 – Nature Communications 9 DOI: 10.1038/s41467-018-06533-2
Steinhorn B, Sartoretto J, Sorrentino A, Kalwa H, Romero N, Abel ED, Michel T. Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH oxidase isoforms NOX2 and NOX4. Free Radic Biol Med. 2017, 113:16-25.
Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE Jr. Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood 2016. blood-2015-08-663146.
Kraus BJ, Sartoretto JL, Polak P, Hosooka T, Shiroto T, Eskurza I, Lee SA, Jian H, Michel T, and Kahn B. Novel role for Retinol-Binding Protein 4 in the regulation of blood pressure. FASEB J 2015, doi: 10.1096/fj.14-266064 fj.14-266064. PMID: 25911613
Tarrago L, Péterfi Z , Lee BC, Michel T, and Gladyshev V. Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors. Nature Chem Biol 2015, 11: 332-338. PMID: 25799144.
Wang L, Hageman TL, Kalwa H, Michel T, Messing A, and Feany MB. Nitric oxide mediates glial-induced neurodegeneration in Alexander disease. Nature Communications 2015, 6:8966-8972.
Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, Isabel Tavares de Almeida I, Blom HJ , Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, and Handy DE. Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase-1 expression. J Biol Chem 2014, 289:15350-15362, doi: 10.1074.jbc.M114.549782. PMID: 24719327
Kalwa H, Sartoretto J, Martinelli R, Romero N, Steinhorn B, Tao M, Ozaki K, Carman C, Michel T A central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium. Proc Nat Acad Sci USA 2014, Mar 4;111(9):3383-8. doi: 10.1073/pnas.1320854111. PMID:24550450
Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang K-T, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce C, Tanaka R, Arany Z. Endothelial PGC-1α mediates vascular dysfunction in diabetes. Cell Metabolism 2014, , Feb 4;19(2):246-58. doi: 10.1016/j.cmet.2013.12.014.. PMID: 24506866
Shiroto T, Romero N, Sugiyama T, Sartoretto J, Kalwa H, Yan Z, Shimokawa H, Michel T. Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS ONE 2014, 9(2): e87871. doi:10.1371/journal.pone.0087871. PMID: 24498385
Bréton-Romero R, Kalwa H, Lamas S, Michel T. Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells. Bioch Biophys Acta Molec Cell Res 2013, Jun 25. pii: S0167-4889(13)00232-2. PMID: 23806663.
Ersoy B, Tarun A, D’Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD and Cohen DE. Phosphatidylcholine Transfer Protein interacts with Thioesterase Superfamily Member 2 to attenuate insulin signaling. Science Signaling 30 July 2013 6 (286), ra64. [DOI: 10.1126/scisignal.2004111].
Tatematsu S, Francis S, Natarajan P, Rader D, Saghatelian A, Brown J, Michel T and Plutzky J. Endothelial lipase determines HDL-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol 2013 Aug; 33(8):1788-94. PMID: 23723371
Jin B, Lin AJ, Golan DE and Michel T. MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability. Proc Natl Acad Sci USA 2012, 109 (37) 14864–14869. PMID: 22927426
Kalwa H, Sartoretto JL, Sartoretto S, and Michel T. Angiotensin-II and MARCKS: a hydrogen peroxide- and Rac1-dependent signaling pathway in vascular endothelium. J Biol Chem 2012, 287: 29147-29158. PMID: 22773836
Kou R, Shiroto T, Sartoretto JL and Michel T. Suppression of Gassynthesis by simvastatin in vascular endothelial cells. J Biol Chem 2012, 287:2643-51. PMID: 22144680
Sartoretto JL, Kalwa H, Shiroto T, Pluth M, Lippard S and Michel T. Role of Ca2+ in the control of H2O2-modulated phosphorylation pathways leading to eNOS activation in cardiac myocytes. PLOS ONE 2012, 7(9): e44627. doi:10.1371/journal.pone.0044627. PMID: 22970272
Kalwa H and Michel T. The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells. J Biol Chem 2011, 286: 2320-2333. PMID: 21097841
Sartoretto J, Kalwa H, Pluth M, Lippard S and Michel T. Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis. Proc Natl Acad Sci USA 2011, 108:15792-15797. PMID: 21896719
Sugiyama T and Michel T. Thiol-metabolizing proteins and endothelial redox state: Differential modulation of eNOS and biopterin pathways. Am J Physiol Heart Circ Phys 2010, 298: H194-H201.
Hess CN, Kou R, Johnson R, Li GK and Michel T. ADP signaling in vascular endothelial cells: ADP-dependent eNOS activation requires the expression but not the kinase activity of AMP-activated Protein Kinase. J Biol Chem 2009, 284:32209-32224. PMID: 19783664
Jin B, Sartoretto J, Gladyshev V, and Michel T. Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-induced AMP-activated protein kinase activation in endothelial cells. Proc Natl Acad Sci USA 2009, 106:17343-17348.
Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J. PPAR-gamma in the endothelium regulates metabolic responses to high-fat diet in mice. J Clin Invest. 2009 119:110-24.
Kou R, Sartoretto J and Michel T. Regulation of Rac1 by simvistatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-β. J Biol Chem 2009, 2004: 14734-43.
Sartoretto J, Jin B, Bauer M, Gertler F, Liao R and Michel T. Regulation of VASP phosphorylation in cardiac myocytes: Differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. Am J Physiol Heart Circ Phys 2009, 297:H1697-H1710 .
Sugiyama T, Levy B and Michel T. Tetrahydrobiopterin recycling: a key determinant of eNOS-dependent signaling pathways in vascular endothelium. J Biol Chem, 2009, 284: 12691 – 12700.
Chen H, Levine Y, Golan DE, Michel T, and Lin AJ. ANP-initiated cGMP pathways regulate VASP phosphorylation and angiogenesis in vascular endothelium. J Biol Chem 2008 283:4439-47.
Atochin D et al. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest 2007 117:1961–7.
Kou R and Michel T. Epinephrine regulation of eNOS: roles of Rac1 and β3-adrenergic receptors in endothelial NO signaling. J Biol Chem 2007 282: 13719-29.
Levine Y, Li GK and Michel T. Agonist-modulated regulation of AMPK-activated protein kinase in endothelial cells: Evidence for an AMPK-Rac1-Akt-eNOS pathway. J Biol Chem 2007, 282:20351-2036
Chen HJ and Michel T. Insulin signaling in vascular endothelial cells: a key role for heterotrimeric G proteins revealed by siRNA-mediated Gβ1 knockdown. Biochemistry 2006 45, 8023-33
Erwin PA, Mitchell D, Marletta M and Michel T. Subcellular targeting and S-nitrosylation of endothelial nitric oxide synthase. J Biol Chem 2006, 281:151-7.
Gonzalez E, Kou R and Michel T. Rac1 and modulation of PI3-kinase pathways in vascular endothelial cells. J Biol Chem 2006, 281:3210-6.
Erwin PA, Lin A, Golan DE and Michel T. Receptor-regulated dynamic S-nitrosylation of endothelial nitric oxide synthase in vascular endothelial cells. J Biol Chem 2005, 280: 19888-94.
Kou R, SenBannerjee S, Jain M and Michel T. Differential regulation of vascular endothelial growth factor receptors revealed by RNA interference: interactions of VEGFR-1 and VEGFR-2 in endothelial cell signaling. Biochemistry 2005, 44:15064-73.
Mitchell DA, Erwin PA, Michel T, and Marletta MA. S-Nitrosation and regulation of inducible nitric oxide synthase. Biochemistry 2005; 44: 4636-47.
Greif DE, Sacks DB and Michel T. Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proc Natl Acad Sci USA 2004 10:1165-70.
Gonzalez E, Nagiel A, Lin A, Golan DE and Michel T. siRNA-mediated downregulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. J Biol Chem 2004, 279: 20659-69.
SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM Kumar A, Feinberg MW, Chen Z, Simon DI, Lusinskas EW, Michel T, Gimbrone MA, Garcia-Cardena G and Jain MK. KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med 2004 199: 1305-15.
Dantas AP, Igarashi J and Michel T. Sphingosine 1-phosphate and control of vascular tone. Am J Physiol Heart Circ Physiol. 2003 284:H2045-52.
Igarashi J, Erwin P, Dantas AP, Chen, H and Michel T. VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors. Proc Natl Acad Sci U S A. 2003 100:10664-9.
Jobin CM, Chen H, Lin AJ, Yacono PW, Igarashi J, Michel T, Golan DE.; Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells. Biochemistry. 2003 42:11716-25.
Thatte HS, Biswas KS, Najjar SF, Birjiniuk V, Crittenden MD, Michel T, Khuri SF. Multi-photon microscopic evaluation of saphenous vein endothelium and its preservation with a new solution, GALA. Ann Thorac Surg. 2003 75:1145-52.
Gonzalez E, Kou R, Lin AJ, Golan DE, and Michel T. Subcellular targeting and agonist-induced site-specific phosphorylation of eNOS. J Biol Chem 2002, 277:39554-60.
Greif D, Kou, R and Michel T. Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase PP2A: Evidence for crosstalk between phosphorylation sites. Biochemistry 2002, 41: 15845-53.
Kou R, Greif D, and Michel T. Dephosphorylation of endothelial nitric oxide synthase by vascular endothelial growth factor: Implications for the vascular responses to cyclosporin. J Biol Chem 2002, 277: 29669-73.
Kou R, Igarashi J and Michel T. Lysophosphatidic acid and receptor-mediated regulation of endothelial nitric oxide synthase. Biochemistry 2002, 41:4982-8.
Antolín JA, Lopez MJ, Klatt P , Soria J, Michel T, Lamas S. Synthesis of peroxynitrite by vascular endothelial cells exposed to cyclosporine. FASEB J 2001; 15:1292-5.
Biswas KS, Thatte HS, Najjar SF, Rhee JH, Birjiniuk V, Crittenden MD, Michel T and Khuri SF. Multiphoton microscopy applications in the evaluation of human saphenous vein. J Surg Res 2001; 93:37-43.
Igarashi J, Bernier SG and Michel T. Sphingosine 1-phosphate and activation of endothelial nitric oxide synthase: Differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors. J Biol Chem, 2001; 276: 12420-6.
Igarashi J, Michel T. Sphingosine 1-phosphate modulates isoform-specific activation of phosphoinositide 3-kinase-β in vascular endothelial cells: implications for eNOS regulation by G-protein coupled receptors. J Biol Chem, 2001; 276:36281-8.
Rakhit A, Maguire CT, Wakimoto H, Gehrmann J, Li GK, Kelly RA, Michel T, Berul C. In Vivo electrophysiology studies in endothelial nitric oxide synthase-deficient mice. J Cardiovasc Electrophysiol, 2001; 11:1295-301.
Thatte H, Biswas N, Najjar SF, Rhee JH, Birjuniuk V, Michel T and Khuri S. Multiphoton microscopy in imaging of human saphenous vein. J Surg Res 2001; 95:37-43.
Trimmer B, Aprille J, Dudzinski D, Lagace C, Lewis S, Michel T and Zayas R.; Regulation of firefly flashing by nitric oxide. Science 2001; 292:2486-8.
Bernier SG, Haldar S and Michel T. Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric oxide synthase. J Biol Chem 2000, 275:30707-15.
Igarashi J and Michel T. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae: eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem 2000, 275:32,363-70.
Kubota I, Han X, Opel DJ, Zhao Y, Baliga R, Huang P, Fishman M, Shannon R, Michel T, and Kelly RA. Increased susceptibility to development of triggered activity in myocytes from mice with targeted disruption of endothelial nitric oxide synthase. J Mol Cell Cardiol 2000, 32:1239-48.
Prabhakar P, Cheng V, and Michel T. A chimeric transmembrane domain directs eNOS palmitoylation and targeting to plasmalemmal caveolae. J Biol Chem 2000; 275:19416-21.
Goetz R, Thatte H, Prabhakar P, Cho M, Michel T and Golan D. Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase. Proc Nat Acad Sci USA 1999; 96:2788-93.
Igarashi J, Thatte H, Prabhakar P, Golan D and Michel T. Calcium-independent activation of endothelial nitric oxide synthase by ceramide. Proc Nat Acad Sci USA1999; 96:12583–8.
Yeh DC , Duncan JA, Yamashita S, and Michel T. Depalmitoylation of endothelial nitric oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca2+-calmodulin. J Biol Chem 1999; 274:33,148–54.
Feron O, Dessy C, Opel DJ, Arstall M, Kelly RA and Michel T. Modulation of the endothelial nitric oxide synthase-caveolin interaction in cardiac myocytes: implications for the autonomic regulation of heart rate. J Biol Chem 1998; 273: 30249-54.
Feron O, Michel JB, Sase K and Michel T. Dynamic regulation of endothelial nitric oxide synthase: complementary roles of dual acylation and caveolin interactions. Biochemistry 1998; 37:193-200.
Feron O, Saldana F, Michel JB and Michel T. The endothelial nitric oxide synthase-caveolin regulatory cycle. J Biol Chem 1998; 273:3125-8.
Han X, Opel D, Feron O, Huang P, Fishman M, Michel T and Kelly RA. Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase. Proc Nat Acad Sci USA 1998; 95:6510-5.
Prabhakar P, Thatte H, Goetz R, Cho M, Golan D and Michel T. Receptor-mediated redistribution of endothelial nitric oxide synthase. J Biol Chem 1998; 273: 27,389-93.
Teng BQ, Murthy KS, Kuemmerle JF, Griader JR, Sase K, Michel T and Makhlouf GM. Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells. Amer J Physiol 1998; 275: G231-G351.
Belhassen L, Feron O, Kaye TM, Michel T and Kelly RA. Regulation by cyclic AMP of post-translational processing and subcellular targeting of endothelial nitric oxide synthase in cardiac myocytes. J Biol Chem 1997; 272:11198-204.
Feron O, Smith TW, Michel T and Kelly RA. Dynamic targeting of the agonist-stimulated m2 muscarinic cholinergic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem 1997; 272: 17,744-8.
Michel JB, Feron O, Prabhakar P, Sase K and Michel T. Caveolin versus calmodulin: counterbalancing allosteric regulators of endothelial nitric oxides synthase. J Biol Chem 1997; 272: 25,907-12.
Michel JB, Feron O, Sacks D and Michel T. Reciprocal regulation of endothelial nitric synthase by caveolin and calmodulin. J Biol Chem 1997; 272, 15583-6.
Michel JB, Michel T. Expression of protein palmitoylthiotransferase-1 in endothelial cells: role in endothelial nitric oxide synthase de-palmitoylation. FEBS Lett 1997; 405:356-62.
Buttery, LDK, Chester AH, Springall DR, Borland JAA, Michel T, Yacoub MH and Polak JM. Explanted vein grafts with an intact endothelium demonstrate reduced focal expression of endothelial nitric oxide synthase specific to atherosclerotic sites. J Pathol 1996; 179:197-203.
Feron O, Belhassen, L, Kobzick L, Smith TW, Kelly RA and Michel T. Endothelial nitric oxide synthase targeting to caveolae: specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem 1996; 271:22810-4.
Robinson, LJ, Ghanouni P and Michel, T. Post-translational modifications of endothelial nitric oxide synthase. Methods in Enzymology 1996; 268:436-48.
Robinson, LJ and Michel T. Expression of endothelial nitric oxide synthase in heterologous cell systems. Methods Enzymol 1996; vol 269, 55-64.
Shaul P, Smart E, Robinson LJ, German Z, Ying Y, Anderson RGW and Michel T.; Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae. J Biol Chem 1996; 271: 6518-23.
Balligand, JL, Kobzik L, Han X, Kaye DM, Belhassen L, O’Hara DS, Kelly RA, Smith TW and Michel T. Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem 1995, 270:14582-6.
Balligand JL, Ungureaunu-Longrois D, Simmons W, Kopzik L, Lamas S, Lowenstein C, Kelly RA, Smith TW and Michel T. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1β and IFN-γ. Amer J Physiol 1995; 268: H1293-H1303.
Busconi L and Michel T. Recombinant endothelial nitric oxide synthase: post-translational modifications in a baculovirus expression system. Mol Pharm 1995, 47:655-9.
Lee CM, Robinson LJ and Michel T. Oligomerization of endothelial nitric oxide synthase: co-immunoprecipitation of wild-type and mutant enzymes in transfected cells. J Biol Chem 1995; 270:27403-06.
Robinson LJ, Busconi L and Michel T. Agonist-modulated palmitoylation of endothelial nitric oxide synthase. J Biol Chem, 1995; 270:995-8.
Robinson LJ and Michel T. Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting. Proc Nat Acad Sci USA 1995; 92:11776-80.
Sase K and Michel T. Expression of constitutive endothelial nitric oxide synthase in human blood platelets. Life Sci 1995; 57:2049-55.
Ungureanu-Longrois D, Balligand J-L, Okada I, Simmons WW, Kobzik L, Kunkel SL, Michel T, Kelly RA and Smith TW. Conctractile responsiveness of ventricular myoctes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Circ Res 1995, 77:486-93.
Ungureanu-Longrois D, Balligand JL, Simmons WW, Okada I, Kobzik L, Kunkel SL, Michel T, Kelly RA and Smith TW. Induction of nitric oxide synthase activity by cytokines is necessary but not sufficient to decrease contractile responsiveness to β-adrenergic agonists. Circ Res 1995, 77:494-502.
Balligand JL, Ungureaunu-Longrois D, Simmons W, Lowenstein C, Malinski T, Kelly RA, Smith TW and Michel T. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes: characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J Biol Chem 1994; 169:27580-8.
Busconi L and Michel T. Endothelial nitric oxide synthase membrane targeting: evidence against involvement of a specific myristate receptor. J Biol Chem 1994; 269: 25016-20
Buttery LDK, McCarthy A, Springall DR, Sullivan MHF, Elder MG, Michel T and Polak JM. Endothelial nitric oxide synthase in the human placenta: regional distribution and proposed regulatory role at the feto-maternal interface. Placenta 1994; 15: 257-65.
Robinson LJ, Weremowicz S, Morton CJ and Michel T. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene. Genomics 1994; 19: 350-7.
Shaul PW, North AJ, Wu LC, Wells LB, Mannon TS, Lau KS, Michel T, Margraf LR and Star RA. Endothelial NO synthase is expressed in airway epithelial cells. J Clin Invest, 1994; 94:2231-36.
Balligand, JL, Kelly RA, Marsden P, Smith TW and Michel T. Control of cardiac muscle cell function by an endogenous nitric oxide synthase signaling system. Proc Nat Acad Sci USA 1993; 90:347-51.
Balligand JL, Ungureanu D, Kelly RA, Kobzik L, Pimental D, Michel T and Smith TW. Induction of nitric oxide synthesis in adult rat cardiac myocytes following exposure to activated macrophage-conditioned medium decreases contractile responses to isoproterenol. J Clin Invest 1993; 91:2314-9.
Busconi L and Michel T. Endothelial nitric oxide synthase: N-terminal myristoylation determines subcellular localization. J Biol Chem 1993, 268:8410-3.
Michel T, Li GK and Busconi L. Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. Proc Nat Acad Sci USA 1993; 90:6252-6.
Lamas S, Marsden PA, Li GK, Tempst P and Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Nat Acad Sci USA 1992; 89:6348-52.
Lamas S, Michel T, Collins T, Brenner BM and Marsden PA. Effects of interferon-gamma on NO synthase activity and endothelin-1 expression in vascular endothelial cells. J Clin Invest 1992; 90:879-87.
Stamler JA, Simon D, Jaranki O, Mullins M, Michel T, Singel D, Loscalzo J.; S-nitrosylation of proteins by nitric oxide: formation of novel biologically active compounds. Proc Nat Acad Sci USA 1992; 89: 444-8.
Willich SN, Tofler GH, Brezinski DA, Schafer AI, Muller JE, Michel T, Colucci WS. Platelet alpha2 adrenoceptor characteristics during the morning increase in platelet aggregability. Eur Heart J 1992; 13:550-5.
Marsden PA, Schappert KT, Chen HS, Flowers M, Sundell CL, Wilcox JN, Lamas S and Michel T. Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett 1992; 307:287-93.
Cui Z, Zubiaur M, Michel T, Seidman JG, Neer EJ. Transfection of a G protein alpha subunit alters agonist-specific growth regulation in cultured fibroblasts. J Biol Chem 1991; 266:20276-82.
Lamas S, Michel T, Brenner BM, Marsden PA. Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by tumor necrosis factor-alpha. Amer J Physiol 1991; 261: C634-C641.
Silbert S, Michel T, Lee RJ, Neer EJ. Differential degradation rates of the G protein alphao in cultured cardiac and pituitary cells. J Biol Chem 1990; 265:3102-5.
Ridker PM, Michel T. Streptokinase therapy and cholesterol embolization. Am J Med 1989; 87:357-8.
Neer EJ, Michel T, Eddy R, Shows T, Seidman JG. Genes for two homologous G proteins map to different human chromosomes. Hum Genet 1987; 77:259-62.
Michel T, Winslow J, Smith J, Seidman JG, Neer EJ. Molecular cloning and characterization of cDNA encoding the G protein αi, and identification of a related protein αh. Proc Nat Acad Sci USA 1986; 83: 7663-8.
Garcia-Sainz JA, Boyer JL, Michel T, Sawyer D, Dohlman H, Lefkowitz RJ.; Effects of pertussis toxin on alpha2-adrenergic receptors: decreased formation of the high affinity state for agonists. FEBS Lett 1984; 172:95-8.
Nambi P, Sibley DR, Stadel JM, Michel T, Peters JR, Lefkowitz RJ. Cell-free desensitization of catecholamine-sensitive adenylate cyclase: agonist and cyclic AMP-promoted alterations of turkey erythrocyte beta-adrenergic receptor. J Biol Chem 1984; 259:4623-33.
Hoffman BB, Michel T, Brenneman T, Lefkowitz RJ. Interactions of agonists with platelet α2 adrenergic receptors. Endocrinology 1982; 110:926-32.
Michel T, Lefkowitz RJ. Hormonal inhibition of adenylate cyclase: alpha2 adrenergic receptors promote release of [3H] guanylylimidodiphosphate from platelet membranes, J. Biol Chem 1982; 257:13557-63.
Michel T, Hoffman BB, Leflowitz RJ, Caron MG. Different sedimentation properties of agonist- and antagonist-labeled platelet α2 – adrenergic receptors. Biochem Biophys Res Comm 1981; 100:1131-6.
Hoffman BB, Michel T, Kilpatrick DM, Lefkowitz RJ, Tolbert EM, Gilman H, Fain J. Agonist versus antagonist binding to the alpha adrenergic receptors. Proc Nat Acad Sci USA 1980; 77:4569-73.
Michel T, Hoffman BB, Lefkowitz RJ. Differential regulation of the α2adrenergic receptor by Na+ and guanine nucleotides. Nature 1980; 288:709-11.
Michel T, Legator MS. DNA repair synthesis and cytogenetic aberrations induced in vivo by triethylenemelamine. Mutation Res 1974; 23:41-6.