Here you can find some of our recent publications. To see more of our work go to original articles or selected reviews.
- D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress.
- Spyropoulos F, Michel T.
- Curr Opin Chem Biol. 2024 Apr;79:102438. doi: 10.1016/j.cbpa.2024.102438. Epub 2024 Feb 27.PMID: 38417321 Review.
- Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
- Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, Chen P, Zhang H, Junqueira C, Amgalan D, Liang FG, Zhang J, Evavold CL, Hafner-Bratkovič I, Zhang Z, Fontana P, Xia S, Waldeck-Weiermair M, Pan Y, Michel T, Bar-Peled L, Wu H, Kagan JC, Kitsis RN, Zhang P, Liu X, Lieberman J.
- Immunity. 2023 Nov 14;56(11):2523-2541.e8. doi: 10.1016/j.immuni.2023.10.004. Epub 2023 Nov 3.PMID: 37924812
- Investigation of alternative two-phase solvent systems for purification of natural products by centrifugal partition chromatography.
- Michel T, Loyet C, Boulho R, Eveno M, Audo G.
- Phytochem Anal. 2024 Mar;35(2):401-408. doi: 10.1002/pca.3298. Epub 2023 Oct 23.PMID: 37872711
- Phytochemical study of Boswellia dalzielii oleo-gum resin and evaluation of its biological properties
- Massei K, Michel T, Obersat GI, Al-Harrasi A, Baldovini N.
- Phytochemistry. 2023 Sep;213:113751. doi: 10.1016/j.phytochem.2023.113751. Epub 2023 Jun 10.PMID: 37307887
- Sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress in chemogenetic transgenic mouse lines.
- Yadav S, Waldeck-Weiermair M, Spyropoulos F, Bronson R, Pandey AK, Das AA, Sisti AC, Covington TA, Thulabandu V, Caplan S, Chutkow W, Steinhorn B, Michel T.
- Nat Commun. 2023 May 29;14(1):3094. doi: 10.1038/s41467-023-38961-0. PMID: 37248315; PMCID: PMC10227029.
- Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology.
- Steinhorn B, Eroglu E, Michel T.
- Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:551-571. doi: 10.1146/annurev-pharmtox-012221-082339. Epub 2021 Sep 16. PMID: 34530645.
- Metabolomic and transcriptomic signatures of chemogenetic heart failure.
- Spyropoulos F, Sorrentino A, van der Reest J, Yang P, Waldeck-Weiermair M, Steinhorn B, Eroglu E, Saeedi Saravi SS, Yu P, Haigis M, Christou H, Michel T.
- Am J Physiol Heart Circ Physiol. 2022 Mar 1;322(3):H451-H465. doi: 10.1152/ajpheart.00628.2021. Epub 2022 Jan 28. PMID: 35089810.
- Dissecting in vivo and in vitro redox responses using chemogenetics.
- Waldeck-Weiermair M, Yadav S, Spyropoulos F, Krüger C, Pandey AK, Michel T.
- Free Radic Biol Med. 2021 Dec;177:360-369. doi: 10.1016/j.freeradbiomed.2021.11.006. Epub 2021 Nov 6. PMID: 34752919; PMCID: PMC8639655.
- Complexities of the chemogenetic toolkit: Differential mDAAO activation by d-amino substrates and subcellular targeting.
- Erdogan YC, Altun HY, Secilmis M, Ata BN, Sevimli G, Cokluk Z, Zaki AG, Sezen S, Akgul Caglar T, Sevgen İ, Steinhorn B, Ai H, Öztürk G, Belousov VV, Michel T, Eroglu E.
- Free Radic Biol Med. 2021 Dec;177:132-142. doi: 10.1016/j.freeradbiomed.2021.10.023. Epub 2021 Oct 20. PMID: 34687864; PMCID: PMC8639799.
- Differential endothelial signaling responses elicited by chemogenetic H2O2 synthesis.
- Saeedi Saravi SS, Eroglu E, Waldeck-Weiermair M, Sorrentino A, Steinhorn B, Belousov V, Michel T.
- Redox Biol. 2020 Sep;36:101605. doi: 10.1016/j.redox.2020.101605. Epub 2020 Jun 16. PMID: 32590330; PMCID: PMC7322171.
- Ultrasensitive genetically encoded indicator for intracellular hydrogen peroxide identifies novel roles for cellular oxidants in cell migration and mitochondrial function.
- Pak VV…Michel T, Vriz S, Messens J, Belousov VV.
- Cell Metabolism 2020, 31:642-653.
- Redox a la Carte: Novel chemogenetic models of heart failure.
- Sorrentino A and Michel T.
- British Journal of Pharmacology 2020, DOI: 10.1111/bph.15093.
- Differential endothelial signaling responses elicited by chemogenetic hydrogen peroxide synthesis.
- Saravi S, Eroglu E, Waldeck-Weiermair M, Sorrentino A, Steinhorn B, Belousov V, Michel T.
- Redox Biology 2020, 36:101605, https://doi.org/10.1016/j.redox.2020.101605.
- Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress.
- Sorrentino A, Steinhorn B, Troncone L, Badole SL, Saravi SSS, Eroglu E, Kijewski MF, Divakaran S, Di Carli M, Michel T.
- Am J Physiol Heart Circ Physiol. 2019 317: H617-H626. PMCID:PMC6766720.
- Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods.
- Eroglu E, Saravi S, Sorrentino A, Steinhorn B, Michel T.
- Proc Natl Acad Sci USA 2019, 116:20210-20217. PMID: 31527268.
We discovered that eNOS phosphorylation does not necessarily lead to enzyme activation. For many years, we and many others had used eNOS phosphorylation as a surrogate for enzyme activation. Using the hydrogen peroxide biosensor HyPer, we discovered a marked discordance between eNOS phosphorylation and increased NO generation in cultured endothelial cells. See:
Also check out our publication of a novel chemogenetic heart-failure model system published in Nature Communications:
Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress
Andrea Sorrentino, Benjamin Steinhorn, Luca Troncone, Seyed Soheil Saravi, Sachin L Badole, Emrah Eroglu, Marie Foley Kijewski, Sanjay Divakaran, Marcelo Di Carli, Thomas Michel
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
Benjamin Steinhorn, Andrea Sorrentino, Sachin Badole, Yulia Bogdanova, Vsevolod Belousov & Thomas Michel
- Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH oxidase isoforms NOX2 and NOX4.
- Steinhorn B, Sartoretto J, Sorrentino A, Kalwa H, Romero N, Abel ED, Michel T.
- Free Radic Biol Med. 2017, 113:16-25.
- Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors.
- Tarrago L, Péterfi Z , Lee BC, Michel T, and Gladyshev V.
- Nature Chem Biol 2015, 11: 332-338. PMID: 25799144.
- A central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium.
- Kalwa H, Sartoretto J, Martinelli R, Romero N, Steinhorn B, Tao M, Ozaki K, Carman C, Michel T
- Proc Nat Acad Sci USA 2014, Mar 4;111(9):3383-8. doi: 10.1073/pnas.1320854111. PMID:24550450
- Rondo in E: Nitroglycerin, nitric oxide, and endothelial therapeutics.
- Steinhorn B, Loscalzo J and Michel T.
- New England Journal of Medicine 2015; 373:277-280.