Here you can find some of our featured publications. To see more of our work go to original articles or selected reviews

Check out our recent publication of a novel chemogenetic heart-failure model system published in Nature Communications:

Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress

Andrea Sorrentino, Benjamin Steinhorn, Luca Troncone, Seyed Soheil Saravi, Sachin L Badole, Emrah Eroglu, Marie Foley Kijewski, Sanjay Divakaran, Marcelo Di Carli, Thomas Michel

Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction

Benjamin Steinhorn, Andrea Sorrentino, Sachin Badole, Yulia Bogdanova, Vsevolod Belousov & Thomas Michel

Fig. 1

  • Steinhorn B, Sartoretto J, Sorrentino A, Kalwa H, Romero N, Abel ED, Michel T.  Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH oxidase isoforms NOX2 and NOX4. Free Radic Biol Med. 2017, 113:16-25.
  • Tarrago L, Péterfi Z , Lee BC, Michel T, and Gladyshev V. Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors. Nature Chem Biol 2015, 11: 332-338. PMID: 25799144.
  • Kalwa H, Sartoretto J, Martinelli R, Romero N, Steinhorn B, Tao M, Ozaki K, Carman C, Michel T A central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium. Proc Nat Acad Sci USA 2014, Mar 4;111(9):3383-8. doi: 10.1073/pnas.1320854111.  PMID:24550450
  • Steinhorn B, Loscalzo J and Michel T. Rondo in E: Nitroglycerin, nitric oxide, and endothelial therapeutics.  New England Journal of Medicine  2015; 373:277-280.