Selected Review Articles


Nitric oxide, the active ingredient in important cardiovascular drugs such as nitroglycerin, is synthesized by a family of nitric oxide synthases.  In the early 1990’s, more than a century after the first use of nitroglycerin for treatment of angina pectoris, molecular clones for nitric oxide synthases were isolated and characterized.  Much has been learned in recent years about the regulation of this important family of proteins, their physiological roles, and their dysregulation in important cardiovascular disease states such as diabetes and hypercholesterolemia.  These review articles span more than a decade of work by my lab and by many others in this active area of investigation.


  • Steinhorn B, Loscalzo J and Michel T. Rondo in E: Nitroglycerin, nitric oxide, and endothelial therapeutics. New England Journal of Medicine 2015; 373:277-280.
  • Sartoretto J, Kalwa H, Romero N, and Michel T.  In vivo imaging of NO and H2O2 in cardiac myocytes.  Methods in Enzymology 2013, 528:61-78. PMID:23849859. PDF
  • Michel T. R is for Arginine. Circulation 2013, 128:1400-1404. PDF
  • Maron BA and Michel T.  Subcellular localization of oxidants and regulation of endothelial nitric oxide synthase.  Circulation Journal 2012, 76 :2497-2512. PMID: 23075817. PDF
  • Michel T. NO way to relax: the complexities of coupling nitric oxide synthase pathways in the heart. Circulation 2010, 121:484-486. PDF
  • Igarashi J, Michel T. Editorial: Endothelial cell-derived S1P. Circulation Research. 2008;102:630-632. PDF
  • Lamas S, Lowenstein C, Michel T. Nitric oxide signaling comes of age: 20 years and thriving. Cardio Research. 2007; 75:207-209. PDF
  • Dudzinski D, Michel T. Life history of eNOS: Partners and Pathways. Cardio Research. 2007; 75: 247-260. PDF
  • Dudzinski D, Igarashi J, Greif D, Michel T. Pharmacology and molecular regulation of nitric oxide synthases. Annu Rev Pharmacol Toxicol. 2006;46:235-76. PDF
  • Lowenstein C, Michel T. What’s in a name? eNOS and anaphylactic shock. J Clin Invest. 2006; 116: 2075-78. PDF
  • Igarashi J, Michel T. More sweetness than light? A search for the causes of diabetic vasculopathy. J Clin Invest. 2001;108(10):1425-7. PDF
  • Michel T, Feron O. Nitric oxide synthases: which, where, how, and why? J Clin Invest. 1997;100 (9):2146-52. PDF
  • Michel T. The guide to politically correct cardiology. J Irreprod Results. 1993;38:7-8. PDF