eNOS is expressed in multiple non-endothelial tissues, where the enzyme is involved in processes as diverse as neurotransmission and the modulation of cardiac myocyte function. We recently discovered that hydrogen peroxide plays a critical role in receptor-dependent modulation of eNOS and other signaling proteins in cardiac myocytes.
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- Sartoretto JL, Kalwa H, Shiroto T, Pluth M, Lippard S and Michel T. Role of Ca2+ in the control of H2O2-modulated phosphorylation pathways leading to eNOS activation in cardiac myocytes. PLOS ONE 2012, 7(9): e44627. doi:10.1371/journal.pone.0044627. PDF
- Sartoretto J, Kalwa H, Pluth M, Lippard S and Michel T. Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis. Proc Natl Acad Sci USA 2011, 108: 15792-15797. PDF
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- Balligand JL, Kobzik L, Han X, Kaye DM, Belhassen L, O’Hara DS, Kelly RA, Smith TW, Michel T. Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem. 1995;270:14582-6. PDF
- Balligand JL, Ungureanu-Longrois D, Simmons W, Kobzik L, Lamas S, Lowenstein C, Kelly RA, Smith TW, Michel T. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma. Am J Physiol. 1995;268:H1293-303. PDF
- Balligand JL, Ungureaunu-Longrois D, Simmons W, Lowenstein C, Malinski T, Kelly RA, Smith TW, Michel T. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes: characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J Biol Chem. 1994;169:27580-8. PDF
- Balligand JL, Kelly RA, Marsden P, Smith TW, Michel T. Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci USA. 1993;90 (1):347-51. PDF